Population
Primary-cultured myotubes prepared from forelimbs of wild-type or ryanodine receptor type 3 knockout mice
Comparison
Depolarization under whole-cell patch clamp vs Resting state / wild-type vs RyR3-knockout
Design
Preclinical
Authors
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Voltage sensor suppression of discrete Ca2+ events extends mechanistic insight into developing skeletal muscle; leaves open relevance to mature fibers or disease.
Functional interaction with voltage sensors suppresses the mechanism that activates discrete Ca2+ events in developing skeletal muscle, regardless of RyR3 presence.
Shirokova et al. (1999) studied this question.
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