Why the study?
Hypertension is a major global public health problem and a recognized cause of premature death, but the association of endothelin-1 gene polymorphisms with hypertension in Burmese people required investigation.
Are +138 Ins/del A and +5665 G/T polymorphisms of the endothelin-1 gene associated with hypertension in Burmese people?
Are +138 Ins/del A and +5665 G/T polymorphisms of the endothelin-1 gene associated with hypertension in Burmese people?
Answers are grounded in this paper and cite their sources.
The +138 Ins/del A polymorphism of the endothelin-1 gene is significantly associated with hypertension in the Burmese population, whereas the +5665 G/T polymorphism is not.
BACKGROUND: Hypertension is one of the major public health problems worldwide, and is one of the recognized causes of premature deaths every year in the world. The purpose of this study was to investigate the associations between the + 138 insertion/deletion of adenine (Ins/del A) and + 5665 guanine-to-thymine (G/T) polymorphisms of the endothelin-1 gene and hypertension in the residents of Magway Township, Myanmar. METHODS: This study was a cross-sectional comparative study including 60 hypertensive patients and 60 control subjects in Magway Township, Myanmar. The inclusion criterion for hypertension was blood pressure ≥ 140/90 mmHg or previous diagnosis by a physician as hypertension and/or taking antihypertensive drugs. The control group had blood pressure < 140/90 mmHg and no previous diagnosis of hypertension. The genotyping was done by polymerase chain reaction and restriction fragment length polymorphism method. CONCLUSIONS: This study provides evidence that the + 138 Ins/del A rather than + 5665 G/T polymorphism is associated with hypertension in Burmese people.
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Oo et al. (2022) studied this question.
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