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June 6, 2023Pacing and Clinical Electrophysiology

Sex differences in paroxysmal atrial fibrillation catheter ablation: A difference‐in‐difference propensity score matched analysis

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Why the study?

Whether male and female patients with AF differ in recurrence risk after catheter ablation remains controversial, with baseline characteristic differences often confounding findings.

Does male sex compared to female sex affect the risk of recurrence or complications after catheter ablation in patients with paroxysmal atrial fibrillation?

Population

352 matched patients (176 pairs) with drug-refractory paroxysmal AF undergoing first catheter ablation

Comparison

Male vs female patients

Design

Retrospective propensity score-matched study

Follow-up

Up to 3-year

Authors

YMYibo MaXijing HospitalLGLanyan GuoXijing HospitalCLCheng LiuJiangsu University

Discussion

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Implication

No sex difference in recurrence after matched ablation; leaves open whether unmeasured factors influence outcomes in broader populations.

Structured PICO

Does male sex compared to female sex affect the risk of recurrence or complications after catheter ablation in patients with paroxysmal atrial fibrillation?

P
Population
352 propensity-score matched patients (176 pairs) with drug-refractory paroxysmal atrial fibrillation undergoing their first catheter ablation procedure
I
Intervention
Catheter ablation in male patients
C
Comparator
Catheter ablation in female patients
O
Outcome
Atrial fibrillation recurrencehard clinical

In a propensity-matched cohort of patients with paroxysmal AF, sex did not significantly affect the risk of arrhythmia recurrence or procedure-related complications after first catheter ablation.

Cite This Study

Ma et al. (2023) studied this question.

synapsesocial.com/papers/6a761ccab23c009ac9fbdc3ahttps://doi.org/10.1111/pace.14742

Topics

Atrial fibrillationPersistent AF managementAF ablation outcomesAnticoagulation in AF
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1In-hospital and 12-month follow-up outcome from the ESC-EORP EHRA Atrial Fibrillation Ablation Long-Term registry: sex differences2019 · 67 citations
  2. 2Efficacy of ablation index‐guided pulmonary vein isolation in patients with paroxysmal atrial fibrillation2022 · 6 citations
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  4. 4Predicting atrial fibrillation ablation outcome: The CAAP-AF score2016 · 213 citations
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