Key result
Female sex linked to ~170% higher risk of AF recurrence after catheter ablation vs males.
Why the study?
Catheter ablation restores sinus rhythm in AF but recurrence remains high, and the impact of sex differences on recurrence after ablation is poorly understood.
Does female sex increase the risk of atrial fibrillation recurrence after catheter ablation compared to male sex?
Population
507 AF patients (143 females, 364 males)
Comparison
Female vs male sex
Design
Propensity score matched cohort study
Authors
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Women may have higher AF recurrence risk post-ablation; leaves open need for sex-specific strategies in prospective trials.
Cohort (n=507)
Does female sex increase the risk of atrial fibrillation recurrence after catheter ablation compared to male sex?
Effect estimate: HR 2.70 (95% CI 1.49-4.90)
Absolute Event Rate: 33.6% vs 12.9%
p-value: p=0.001
Female patients have a significantly higher risk of atrial fibrillation recurrence following catheter ablation compared to propensity-matched male patients.
Zhou et al. (2023) conducted a cohort in Atrial fibrillation (AF) (n=507). Female sex vs. Male sex was evaluated on Atrial fibrillation recurrence (HR 2.70, 95% CI 1.49-4.90, p=0.001). Female sex was associated with a higher risk of atrial fibrillation recurrence after catheter ablation compared to male sex (33.6% vs 12.9%; HR 2.70, 95% CI 1.49-4.90, p=0.001).
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