Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
March 24, 2022HeartOpen Access

Women had worse rhythm outcomes after de novo AFCA (HR 1.28, 95% CI 1.02 to 1.59, p=0.031), but better response to antiarrhythmic drugs after postprocedural recurrence compared to men (HR 0.75, 95% CI 0.59 to 0.95, p=0.022).

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Although AF recurrence after catheter ablation is higher in women than men, whether a sex difference exists in antiarrhythmic drug responsiveness among patients with recurrence was unknown.

Does female sex affect atrial fibrillation recurrence after catheter ablation and response to antiarrhythmic drugs compared to male sex in patients undergoing de novo AFCA?

Population

2999 consecutive patients undergoing de novo AFCA

Comparison

Women vs men

Design

Cohort study

Follow-up

48.2±34.9 months

Authors

YPYoon Jung ParkJPJe‐Wook ParkHYHee Tae Yu

Discussion

Loading...

Member takes

Overview

Women with post-AFCA recurrence may respond better to AADs than men, especially if elderly; leaves open sex-specific rhythm strategies.

Structured PICO

Does female sex affect atrial fibrillation recurrence after catheter ablation and response to antiarrhythmic drugs compared to male sex in patients undergoing de novo AFCA?

P
Population
2999 consecutive patients who underwent de novo atrial fibrillation catheter ablation (AFCA), mean age 58.3±10.9 years, 26.5% women, 68.1% paroxysmal AF. Subgroups analyzed include 1094 patients with recurrence and 788 who subsequently underwent rhythm control with antiarrhythmic drugs (AAD).
I
Intervention
Female sex
C
Comparator
Male sex
O
Outcome
Atrial fibrillation recurrence after catheter ablation and atrial fibrillation recurrence under antiarrhythmic drugs

Although women have a higher risk of atrial fibrillation recurrence after initial catheter ablation, they exhibit a better response to antiarrhythmic drugs for postprocedural recurrences compared to men, particularly in older age groups.

Cite This Study

Park et al. (2022) studied this question.

synapsesocial.com/papers/6a8fdb2e1e8f8abc306c86bdhttps://doi.org/10.1136/heartjnl-2021-320601
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sex differences in mapping and rhythm outcomes of a repeat atrial fibrillation ablation2021 · 29 citations
  2. 2Sex Difference in Atrial Fibrillation Recurrence After Catheter Ablation2023
  3. 3Sex differences involved in persistent atrial fibrillation recurrence after radiofrequency ablation2022 · 19 citations
  4. 4Sex‐based differences in safety and efficacy of catheter ablation for atrial fibrillation2023 · 23 citations
  5. 5Sex differences after atrial fibrillation ablation: a patient level meta-analysis2026