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January 22, 2021HeartOpen Access

Female sex was independently associated with clinical recurrences after repeat procedures (HR 1.51, 95% CI 1.06 to 2.15, p=0.023).

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Why the study?

Complication risks and rhythm outcomes differ by sex after AF catheter ablation, prompting evaluation of sex differences in mapping and rhythm outcomes during repeat ablation procedures.

Do mapping and rhythm outcomes differ between women and men undergoing a repeat atrial fibrillation catheter ablation?

Population

443 consecutive patients undergoing a second AFCA from a registry of 3282 patients

Comparison

Women vs men

Design

Registry-based propensity score-matched observational study

Follow-up

Median 31-month (8-60)

Authors

HPHui‐Nam PakJPJe‐Wook ParkSYSong-Yi Yang

Discussion

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Overview

Women show distinct mapping and higher recurrence after repeat AFCA; hypothesis-generating and requires prospective validation before influencing strategies.

Structured PICO

Do mapping and rhythm outcomes differ between women and men undergoing a repeat atrial fibrillation catheter ablation?

P
Population
443 consecutive patients (24.6% female, mean age 58.5±10.3 years, 61.5% with paroxysmal atrial fibrillation) who underwent a second atrial fibrillation catheter ablation, selected from a registry of 3282 patients.
I
Intervention
Female sex (undergoing repeat atrial fibrillation catheter ablation)
C
Comparator
Male sex (undergoing repeat atrial fibrillation catheter ablation)
O
Outcome
Long-term clinical recurrences of atrial fibrillationhard clinical

In patients undergoing repeat atrial fibrillation ablation, women have fewer pulmonary vein reconnections but more extra-PV triggers and elevated LA pressure, leading to a higher risk of clinical recurrence compared to men.

Cite This Study

Pak et al. (2021) studied this question.

synapsesocial.com/papers/6a8fdb2e1e8f8abc306c86c0https://doi.org/10.1136/heartjnl-2020-318282
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sex difference in atrial fibrillation recurrence after catheter ablation and antiarrhythmic drugs2022 · 40 citations
  2. 2Sex-Related Differences in Atrial Remodeling in Patients With Atrial Fibrillation: Relationship to Ablation Outcomes2021 · 109 citations
  3. 3Sex‐based differences in safety and efficacy of catheter ablation for atrial fibrillation2023 · 23 citations
  4. 4Sex differences involved in persistent atrial fibrillation recurrence after radiofrequency ablation2022 · 19 citations
  5. 5Sex differences in atrial fibrillation ablation outcomes: insights from a large-scale multicentre registry2020 · 52 citations