Patients with a genetic background such as a MYRF variant may be susceptible to recurrent MERS, including episodes triggered by SARS-CoV-2 infection, which can be successfully treated with methylprednisolone.
SARS-CoV-2 may trigger recurrent encephalopathy in genetically susceptible children; hypothesis-generating for steroid-responsive mechanisms.
gene, who had five episodes of encephalopathy. She experienced reduced consciousness, numbness in the arm, and impaired verbal communication from day 4 of SARS-CoV-2 infection. Magnetic resonance imaging of her head showed reduced water diffusion in the corpus callosum and deep white matter. These features were similar to those seen in her previous episodes of encephalopathy. She was treated with methylprednisolone pulse therapy and recovered completely within a week.
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