Key result
A 27-year-old female with influenza A-associated MERS achieved full clinical and radiological recovery with conservative management, avoiding the need for corticosteroid therapy.
Why the study?
Mild encephalitis/encephalopathy with a reversible splenial lesion is predominantly reported in pediatric populations, with limited cases documented in adults.
Case Report (n=1)
No
MERS is a rare, self-limiting syndrome that can occur in adults following influenza A infection and typically resolves with supportive care without corticosteroids.
Recognizes MERS in adult post-influenza cases; leaves open the need for prospective data on incidence and management.
Mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) is a rare clinical-radiological entity predominantly reported in pediatric populations, with limited cases in adults. We present a case of a 27-year-old female who developed transient neurological deficits following influenza A infection. She presented with severe headache, neck stiffness, and limb weakness with sensory deficits. Initial suspicion of meningoencephalitis prompted treatment with intravenous antibiotics and antivirals. However, an MRI revealed a hyperintense splenial lesion in the corpus callosum (SCC), supporting a diagnosis of MERS. The patient achieved full recovery without corticosteroids, reinforcing the self-limiting nature of this condition. This case highlights the diagnostic challenges, imaging findings, and management considerations of MERS, underscoring the importance of clinical awareness to avoid unnecessary interventions in adult cases.
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Malik et al. (2025) conducted a case report in Mild Encephalitis/Encephalopathy With a Reversible Splenial Lesion (MERS) (n=1). Conservative management (oseltamivir and supportive care without corticosteroids) was evaluated on Clinical and radiological recovery. A 27-year-old female with influenza A-associated MERS achieved full clinical and radiological recovery with conservative management, avoiding the need for corticosteroid therapy.
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