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October 1, 2025Neurology India Case ReportOpen Access

Brain MRI following syncope reveals a reversible splenial lesion that completely resolves within 30 days.

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Why the study?

Mild encephalopathy with reversible splenial lesion (MERS) is classically described in children, but increasing cases are reported in adults with atypical presentations.

Population

1 adult patient with flu-like symptoms and syncopal episodes

Design

Case report

Follow-up

30 days

Key result

Brain magnetic resonance imaging in a 60-year-old female with flu-like symptoms and syncope revealed a reversible splenial lesion that completely resolved after 30 days.

Authors

GZGabriela ZieglerMGMartin GreccoGPGuillermo Povedano

Discussion

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Overview

May support considering MERS in adult differentials for reversible splenial lesions; hypothesis-generating and requires validation in larger cohorts.

Study Design

Type

Case Report (n=1)

Structured PICO

P
Population
A 60-year-old female with a history of dyslipidemia and endometrial polyps presenting with flu-like symptoms and syncopal episodes, followed for 30 days.
E
Exposure
Brain magnetic resonance imaging (MRI) and follow-up MRI
O
Outcome
Resolution of the lesion in the splenium of the corpus callosumsurrogate

MERS should be considered as a differential diagnosis in adults presenting with a cytotoxic lesion in the corpus callosum, though other etiologies must be ruled out.

Cite This Study

Ziegler et al. (2025) conducted a case report in Mild encephalopathy with reversible splenial lesion (MERS) (n=1). Brain magnetic resonance imaging (MRI) was evaluated on Resolution of the lesion on follow-up MRI. Brain magnetic resonance imaging in a 60-year-old female with flu-like symptoms and syncope revealed a reversible splenial lesion that completely resolved after 30 days.

synapsesocial.com/papers/6aaca8a94963efd150c0d2cbhttps://doi.org/10.4103/nicr.nicr_8_25
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Encephalopathy with a reversible lesion in the splenium of the corpus callosum in adults2024
  2. 2Mild Encephalitis/Encephalopathy With a Reversible Splenial Lesion (MERS) Type II in an Adult: A Case Report and Diagnostic Insight2025
  3. 3Mild encephalitis/encephalopathy with a reversible splenial lesion (MERS): A case report and review of the literature2026
  4. 4Mild Encephalitis/Encephalopathy With a Reversible Splenial Lesion of the Corpus Callosum (MERS): A Report of Two Pediatric Cases2026
  5. 5Clinically mild encephalitis/encephalopathy with a reversible splenial lesion of the corpus callosum in childhood: A single-center experience2021