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August 16, 2026Radiology Case ReportsOpen Access

Mild encephalitis/encephalopathy with a reversible splenial lesion (MERS): A case report and review of the literature

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Key result

Supportive care and antiepileptic therapy resolve the splenial lesion and clinical symptoms in a MERS case.

  • n=1

Population

A 21-year-old male presenting with an acute generalized seizure following an influenza-like illness

Design

Case report and review of the literature

Authors

SESalah Ben ElhendRRRedouane RoukhssiNHNabil HammouneCadi Ayyad University

Discussion

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Overview

MERS after influenza-like illness extends known triggers in adults; hypothesis-generating without practice change.

Key Points

  • To describe the clinical presentation, neuroimaging findings, and disease course of mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) following a viral prodrome.
  • Clinical and radiological evaluation of a 21-year-old male presenting with an acute generalized seizure after an influenza-like illness.
  • Diagnostic assessments included blood biochemistry, cerebrospinal fluid (CSF) analysis, baseline brain MRI (T2, FLAIR, DWI, ADC, and contrast sequences), and post-recovery follow-up MRI.
  • Brain MRI demonstrated a well-defined ovoid, non-enhancing lesion in the midline splenium with T2/FLAIR hyperintensity and restricted diffusion (low ADC values), alongside normal serum and CSF panels.
  • Supportive care and antiepileptic therapy led to complete clinical recovery, with follow-up MRI confirming total resolution of the corpus callosum lesion.

Study Design

Type

Case Report (n=1)

Structured PICO

P
Population
A 21-year-old male presenting with an acute generalized seizure following an influenza-like illness, diagnosed with MERS.
I
Intervention
Supportive care and antiepileptic therapy
O
Outcome
Complete clinical recovery and complete resolution of the splenial lesion on follow-up MRI

This case highlights the importance of recognizing MERS in young patients presenting with post-infectious altered consciousness or new-onset seizures and underscores the central role of MRI in establishing the diagnosis.

Cite This Study

Elhend et al. (2026) conducted a case report in Mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) (n=1). Supportive care and antiepileptic therapy was evaluated on Clinical recovery and resolution of splenial lesion. Supportive care and antiepileptic therapy resulted in complete clinical recovery and MRI-confirmed resolution of the splenial lesion in a 21-year-old male with MERS.

synapsesocial.com/papers/6a817a60f2fb91fc834ae2fdhttps://doi.org/10.1016/j.radcr.2026.03.005
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mild Encephalitis/Encephalopathy With a Reversible Splenial Lesion of the Corpus Callosum (MERS): A Report of Two Pediatric Cases2026
  2. 2Encephalopathy with a reversible lesion in the splenium of the corpus callosum in adults2024
  3. 3Mild Encephalopathy with Reversible Splenial Lesion in an Adult Patient with Atypical Presentation2025
  4. 4Mild Encephalitis/Encephalopathy With a Reversible Splenial Lesion (MERS) Type II in an Adult: A Case Report and Diagnostic Insight2025
  5. 5Clinically mild encephalitis/encephalopathy with a reversible splenial lesion of the corpus callosum in childhood: A single-center experience2021