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October 23, 2025CureusOpen Access

Mild Encephalitis/Encephalopathy With a Reversible Splenial Lesion (MERS) Type II in an Adult: A Case Report and Diagnostic Insight

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Key result

Supportive care and correction of hyponatremia led to complete clinical and radiological resolution of MERS type II within one week in a 28-year-old man.

Why the study?

Mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) is increasingly recognized in pediatric populations but remains underdiagnosed in adults.

Population

One adult presenting with nonspecific neurological symptoms following a respiratory prodrome

Design

Case report

Authors

LZLingling Zhuang

Discussion

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Overview

Supports MERS consideration in adult post-viral encephalopathy; leaves open incidence, prognosis, and management data.

Study Design

Type

Case Report (n=1)

Multicenter

No

Structured PICO

P
Population
A 28-year-old man presenting with acute neurological deterioration following a respiratory prodrome, diagnosed with MERS type II and followed for one week.
I
Intervention
Supportive care, including anti-infectives for concomitant pneumonia and measures to correct hyponatremia.
O
Outcome
Clinical and radiological resolution of symptoms and lesions.

Mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) should be considered in adults presenting with encephalopathy following a prodromal illness, as it has an excellent prognosis with supportive care.

Limitations

  • Patient declined further investigations including EEG, lumbar puncture, and autoimmune testing.

Cite This Study

Lingling Zhuang (2025) conducted a case report in Mild Encephalitis/Encephalopathy With a Reversible Splenial Lesion (MERS) Type II (n=1). Supportive care (anti-infectives and hyponatremia correction) was evaluated on Clinical and radiological resolution. Supportive care and correction of hyponatremia led to complete clinical and radiological resolution of MERS type II within one week in a 28-year-old man.

synapsesocial.com/papers/6a9eecee4f443e6a88b28baahttps://doi.org/10.7759/cureus.95265
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinically mild encephalitis/encephalopathy with a reversible splenial lesion2004 · 554 citations
  2. 2Reversible Splenial Lesion Syndrome (RESLES): What's in a Name?2010 · 250 citations
  3. 3Acute disseminated encephalomyelitis2007 · 632 citations