Mild encephalopathy with reversible splenial lesion (MERS) is a rare clinical-radiological syndrome that can present in children with influenza and typically resolves completely with supportive care.
MERS diagnostic criteria support favorable outcomes in case reports; leaves open etiology and management questions.
Mild encephalopathy with reversible splenial lesion (MERS) is a rare clinical-radiological syndrome with a favorable prognosis that typically presents with central nervous system symptoms such as altered mental status, delirious behavior, seizures, muscle weakness, ophthalmoplegia, and headache. The diagnosis of MERS is based on a constellation of central nervous system symptoms within one week of fever, a lesion in the splenium of the corpus callosum, and complete resolution without sequelae. Both clinical and imaging findings generally resolve within a few months. Treatment is largely supportive care and/or treatment of the primary cause.
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Nmadu et al. (2023) studied this question.