September 24, 2010European Journal of Heart FailureOpen Access

The Cardiac Renin–Angiotensin System is Responsible for High-Salt Diet-Induced Left Ventricular Hypertrophy in Mice

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Why the study?

Does irbesartan or ramipril prevent high-salt diet-induced left ventricular hypertrophy in mice?

Population

Swiss mice

Comparison

High-salt diet plus irbesartan or ramipril for 8… vs Regular salt diet or High-salt diet alone

Design

Preclinical

Follow-up

8 weeks

Authors

PCPhilippe Le CorvoisierInserm CAC. AdamyInserm LSLucien SambinInserm

Discussion

Member takes

Implication

Positive mouse data on RAS blockade for salt-induced LVH; leaves open human translation and clinical relevance.

Structured PICO

Does irbesartan or ramipril prevent high-salt diet-induced left ventricular hypertrophy in mice?

Population

Swiss mice

Intervention

High-salt (HS) diet (4% NaCl) plus irbesartan (50 mg/kg/day) or ramipril (1 mg/kg/day) for 8 weeks

Comparator

Regular salt (RS) diet (0.6% NaCl) or High-salt (HS) diet (4% NaCl) alone

Outcome

Left ventricle/body weight ratio, arterial pressure, collagen density, angiotensin-converting enzyme activity, AT1 receptor density, and ERK1/2 phosphorylationsurrogate

In a mouse model, high-salt diet induces left ventricular hypertrophy and fibrosis via the cardiac RAS-ERK pathway, which can be prevented by treatment with irbesartan or ramipril.

Cite This Study

Corvoisier et al. (2010) studied this question.

synapsesocial.com/papers/6a7623141ee3153e8f613e2f https://doi.org/10.1093/eurjhf/hfq146

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The Cardiac Renin–Angiotensin System is Responsible for High-Salt Diet-Induced Left Ventricular Hypertrophy in Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The Cardiac Renin–Angiotensin System is Responsible for High-Salt Diet-Induced Left Ventricular Hypertrophy in Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider