Why the study?
Treatment of HFpEF remains a major unmet medical need, and an implantable valveless pulsatile pump with a single cannula (CoPulse pump) may provide beneficial hemodynamic support.
Does the CoPulse pump improve hemodynamics and demonstrate hemocompatibility in in vitro and ex vivo models of HFpEF?
Population
In vitro circulatory mock loop and ex vivo isolated porcine heart model
Comparison
CoPulse pump support vs baseline conditions
Design
Preclinical in vitro, ex vivo, and in silico feasibility study
Authors
Loading...
Hypothesis-generating for CoPulse support in HFpEF; leaves open clinical translation pending human trials.
Does the CoPulse pump improve hemodynamics and demonstrate hemocompatibility in in vitro and ex vivo models of HFpEF?
The CoPulse pump demonstrated hemodynamic efficacy and hemocompatibility in vitro and ex vivo, supporting its further development as a mechanical circulatory support device for HFpEF.
Escher et al. (2020) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: