February 1, 2001Journal of Internal Medicine
Marked suppression of renin levels by β‐receptor blocker in patients treated with standard heart failure therapy: a potential mechanism of benefit from β‐blockade
Why the study?
Does beta-blocker therapy reduce plasma renin levels in men with previous MI and LV dysfunction treated with ACE inhibitors and/or diuretics?
Population
312 men with previous myocardial infarction (MI) and echocardiographic left ventricular (LV) dysfunction
Comparison
Beta-blockers in combination with ACE inhibitors… vs ACE inhibitors and/or diuretics without…
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
May support beta-blocker use via renin suppression in post-MI LV dysfunction on ACEi/diuretics; hypothesis-generating and requires prospective confirmation.
Structured PICO
Does beta-blocker therapy reduce plasma renin levels in men with previous MI and LV dysfunction treated with ACE inhibitors and/or diuretics?
P
Population
312 men with previous myocardial infarction (MI) and echocardiographic left ventricular (LV) dysfunction
I
Intervention
Beta-blockers in combination with ACE inhibitors and/or diuretics
C
Comparator
ACE inhibitors and/or diuretics without beta-blockers, or antiplatelet agents alone
O
Outcome
Plasma renin levels measured by direct radioimmunometric assaysurrogate
Concomitant beta-blocker treatment suppresses reactive renin stimulation in patients with LV dysfunction after MI treated with ACE inhibitors and/or diuretics, providing a potential mechanism for their clinical benefit.
Cite This Study
Holmer et al. (2001) studied this question.