Why the study?
Does prolonged prophylaxis with LMWH reduce postoperative venous thrombosis in patients undergoing elective total hip replacement compared to short prophylaxis?
Population
198 patients undergoing elective total hip replacement (109 women, 89 men).
Comparison
Prolonged prophylaxis with low molecular weight… vs Short prophylaxis with low molecular weight…
Design
RCT, Randomised to receive short or prolonged prophylaxis
Authors
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Prolonged LMWH prophylaxis lowers thrombosis risk in APC-resistant hip arthroplasty patients; extends benefit particularly to women with normal FV genotype.
Does prolonged prophylaxis with LMWH reduce postoperative venous thrombosis in patients undergoing elective total hip replacement compared to short prophylaxis?
Prolonged prophylaxis with LMWH after elective hip arthroplasty appears particularly important for women, who demonstrated a higher baseline risk of postoperative venous thrombosis compared to men.
Svensson et al. (1997) studied this question.
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