Why the study?
High-sensitivity cardiac troponin assay manufacturers have restricted acceptable sample matrices, requiring evaluation of assay comparability across different matrices and storage conditions.
Population
Three QC-plasma matrices and samples spanning 2.5 ng/L to <60 ng/L
Comparison
Serum vs lithium heparin plasma vs EDTA plasma and Siemens vs Abbott hs-cTnI assays
Design
In vitro assay validation and matrix comparison study
Authors
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EDTA plasma yields lower hs-cTnI than lithium heparin or serum; leaves open assay-specific matrix standardization for labs.
The Siemens ADVIA Centaur hs-cTnI assay yields lower concentrations in EDTA plasma compared to serum or lithium heparin plasma, requiring specific reference intervals for EDTA samples before clinical use.
Kavsak et al. (2019) studied this question.
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