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February 2, 2005Journal of Cell Science

The Tie-2 ligand Angiopoietin-2 destabilizes quiescent endothelium through an internal autocrine loop mechanism

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Authors

MSMarion ScharpfeneckerLeiden UniversityUFUlrike FiedlerNBE Therapeutics (Switzerland)YRYvonne ReissGoethe University Frankfurt

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Scharpfenecker et al. (2005) studied this question.

synapsesocial.com/papers/6a768921a0847c3df1ec1237https://doi.org/10.1242/jcs.01653
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1ESE-1 Is a Novel Transcriptional Mediator of Angiopoietin-1 Expression in the Setting of Inflammation2004 · 60 citations
  2. 2Designed angiopoietin-1 variant, COMP-Ang1, protects against radiation-induced endothelial cell apoptosis2004 · 146 citations
  3. 3Angiopoietin-1 and Angiopoietin-2 Share the Same Binding Domains in the Tie-2 Receptor Involving the First Ig-like Loop and the Epidermal Growth Factor-like Repeats2003 · 200 citations
  4. 4The Tie-2 ligand Angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies2004 · 749 citations
  5. 5Angiopoietin-1 Is an Antipermeability and Anti-Inflammatory Agent In Vitro and Targets Cell Junctions2000 · 508 citations