Population
In vitro cell models and human synovium tissue from patients with rheumatoid arthritis
Comparison
Exposure to inflammatory cytokines or ESE-1… vs Unstimulated cells or mutated ESE-1 binding site
Design
Preclinical
Authors
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No immediate clinical implications; leaves open ESE-1 as a potential target in inflammatory angiogenesis.
The ETS factor ESE-1 acts as a novel transcriptional mediator of Angiopoietin-1 expression and angiogenesis during inflammation.
Brown et al. (2004) studied this question.
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