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June 11, 2011European Heart JournalOpen Access

Common carotid artery intima-media thickness is as good as carotid intima-media thickness of all carotid artery segments in improving prediction of coronary heart disease risk in the Atherosclerosis Risk in Communities (ARIC) study

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Why the study?

Does adding CCA-IMT and plaque information to traditional risk factors predict incident CHD as well as A-CIMT and plaque information?

Population

12,576 individuals from the Atherosclerosis Risk in Communities (ARIC) study

Comparison

Risk prediction using traditional risk factors +… vs Risk prediction using TRF + all carotid artery…

Design

Cohort

Follow-up

mean 15.2 years

Authors

VNVijay NambiGeneral / Preventive / LipidsLCLloyd E. ChamblessPreventive CardiologyMHM. HeYuxian People's Hospital

Discussion

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Implication

CCA-IMT plus plaque may offer a simpler alternative for CHD risk prediction; leaves open need for prospective validation before practice change.

Structured PICO

Does adding CCA-IMT and plaque information to traditional risk factors predict incident CHD as well as A-CIMT and plaque information?

P
Population
12,576 individuals from the Atherosclerosis Risk in Communities (ARIC) study
I
Intervention
Risk prediction using traditional risk factors (TRF) + common carotid artery intima-media thickness (CCA-IMT) + plaque information
C
Comparator
Risk prediction using TRF + all carotid artery segments intima-media thickness (A-CIMT) + plaque, or TRF alone
O
Outcome
Incident coronary heart disease (CHD) events (assessed via AUC, NRI, and model calibration for 10-year risk prediction)hard clinical

Measuring common carotid artery intima-media thickness (CCA-IMT) with plaque presence is a reliable and easier alternative to measuring all carotid segments for improving CHD risk prediction beyond traditional risk factors.

Cite This Study

Nambi et al. (2011) studied this question.

synapsesocial.com/papers/6a769088e4645e92c9bd38c4https://doi.org/10.1093/eurheartj/ehr192
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1THE ATHEROSCLEROSIS RISK IN COMMUNIT (ARIC) STUDY: DESIGN AND OBJECTIVES1989 · 2,964 citations
  2. 2Completeness of Carotid Intima Media Thickness Measurements Depends on Body Composition: The RADIANCE 1 and 2 trials2010 · 22 citations
  3. 3Carotid Intima-Media Thickness and Presence or Absence of Plaque Improves Prediction of Coronary Heart Disease Risk2010 · 924 citations
  4. 4High‐Resolution B‐Mode Ultrasound Reading Methods in the Atherosclerosis Risk in Communities (ARIC) Cohort1991 · 203 citations
  5. 5B-mode-detected carotid artery plaque in a general population. Atherosclerosis Risk in Communities (ARIC) Study Investigators.1994 · 199 citations