July 1, 2000Cardiovascular Research
Unstable angina activates myocardial heat shock protein 72, endothelial nitric oxide synthase, and transcription factors NFκB and AP-1
Why the study?
Does unstable angina alter the myocardial expression of heat shock proteins, eNOS, and inflammatory transcription factors compared to stable angina?
Population
30 patients undergoing coronary artery bypass grafting (15 with unstable angina, 15 with stable angina)
Comparison
Unstable angina (exposure) vs Stable angina
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
May signal perioperative vulnerability in unstable angina; hypothesis-generating for targeted modulation pending prospective trials.
Structured PICO
Does unstable angina alter the myocardial expression of heat shock proteins, eNOS, and inflammatory transcription factors compared to stable angina?
P
Population
30 patients undergoing coronary artery bypass grafting (15 with unstable angina, 15 with stable angina)
I
Intervention
Unstable angina (exposure)
C
Comparator
Stable angina
O
Outcome
Expression of HSP72, HSP73, eNOS, and activation of NFkappaB and AP-1 in right atrial biopsiessurrogate
Unstable angina is associated with increased myocardial expression of cardioprotective proteins (HSP72, eNOS) and activation of proinflammatory transcription factors (NFkappaB, AP-1), which may influence surgical outcomes.
Cite This Study
Guro Valen (2000) studied this question.