October 27, 1998CirculationOpen Access

Nuclear Factor-κB Is Selectively and Markedly Activated in Humans With Unstable Angina Pectoris

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Population

102 consecutive patients without an acute myocardial infarction undergoing cardiac catheterization…

Design

Cross-sectional

Authors

MRMichael E. RitchieUnited States Department of Veterans Affairs

Discussion

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Implication

NF-κB activation strongly associates with unstable angina; hypothesis-generating for plaque disruption mechanisms and requires prospective validation.

Structured PICO

Population

102 consecutive patients without an acute myocardial infarction undergoing cardiac catheterization, including 19 with unstable angina (within 24 hours of last chest pain) and 83 evaluated for stable angina, valvular heart disease, atypical chest pain, or congestive heart failure.

Outcome

Evidence of NF-kappaB activation in the circulation determined by electromobility shift assays (EMSAs)surrogate

NF-kappaB is selectively and markedly activated in patients with unstable angina pectoris, suggesting a potential mechanistic role in plaque disruption and acute coronary syndromes.

Cite This Study

Michael E. Ritchie (1998) studied this question.

synapsesocial.com/papers/6a758ff272c9f0ed5b5fff12 https://doi.org/10.1161/01.cir.98.17.1707

Topics

Coronary artery disease

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Implication

NF-κB activation strongly associates with unstable angina; hypothesis-generating for plaque disruption mechanisms and requires prospective validation.

Nuclear Factor-κB Is Selectively and Markedly Activated in Humans With Unstable Angina Pectoris

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Nuclear Factor-κB Is Selectively and Markedly Activated in Humans With Unstable Angina Pectoris

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider