June 4, 2015American Journal of HypertensionOpen Access

Clock Genes Explain a Large Proportion of Phenotypic Variance in Systolic Blood Pressure and This Control Is Not Modified by Environmental Temperature

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Population

Participants from the Genetics of Lipid Lowering Drugs and Diet Network and the Boston Puerto Rican Health…

Design

Cohort

Authors

HDHassan S. DashtiHarvard University SAStella Aslibekyan23andMe (United States)FSFrank A. J. L. ScheerGeneral / Preventive / Lipids

Discussion

Member takes

Implication

Clock gene variants explain 7% of SBP variance independent of temperature; leaves open clinical utility pending replication in diverse cohorts.

Structured PICO

Population

Participants from the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) (n = 819) and the Boston Puerto Rican Health Study (BPRHS) (n = 1,248) cohorts.

Outcome

Phenotypic variance in systolic and diastolic blood pressuresurrogate

Clock genes explain a significant proportion of phenotypic variance in systolic blood pressure, independent of environmental temperature.

Cite This Study

Dashti et al. (2015) studied this question.

synapsesocial.com/papers/6a76cd204fe2e6ffd8ec2e66 https://doi.org/10.1093/ajh/hpv082

Topics

Hypertension management

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Implication

Clock gene variants explain 7% of SBP variance independent of temperature; leaves open clinical utility pending replication in diverse cohorts.

Clock Genes Explain a Large Proportion of Phenotypic Variance in Systolic Blood Pressure and This Control Is Not Modified by Environmental Temperature

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Clock Genes Explain a Large Proportion of Phenotypic Variance in Systolic Blood Pressure and This Control Is Not Modified by Environmental Temperature

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider