Interpreting Low Pressure Pullback Gradient in Non-Culprit Lesions With Quantitative Flow Ratio ≥0.80

0.84, remain prognostically relevant.2 Second, lower PPG suggests a less focal distribution of epicardial resistance, whereas plaque vulnerability, including lipid-rich plaque and thin-cap fibroatheroma, has been associated with higher PPG. 3 Thus, comparison of baseline angiographic severity, QFR distribution, and outcomes between low QFR/high QFR-PPG and low QFR/low QFR-PPG lesions would be informative in determining whether the prognostic signal primarily reflects reduced QFR itself or whether low QFR-PPG carries additional meaning beyond QFR.