What question did this study set out to answer?

To determine the effect of a perindopril-based antihypertensive regimen on resistance vessel media-to-lumen ratio and left ventricular mass in patients with essential hypertension.

January 1, 1995Blood Pressure

Normalization of Structural Cardiovascular Changes During Antihypertensive Treatment with a Regimen Based on the ACE-inhibitor Perindopril

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Why the study?

Does a perindopril-based antihypertensive regimen improve media:lumen ratio and left ventricular mass in patients with essential hypertension?

Population

25 patients with newly diagnosed or poorly regulated essential hypertension

Design

Cohort

Follow-up

9 months

Authors

ISInger SihmAarhus University ASAnne SchroederAarhus University Hospital CAChristian AalkjærVascular / Pulmonary Vascular

Discussion

Member takes

Implication

May support vascular and cardiac remodeling with perindopril in essential hypertension; hypothesis-generating and should not yet change practice.

Key Points

To determine the effect of a perindopril-based antihypertensive regimen on resistance vessel media-to-lumen ratio and left ventricular mass in patients with essential hypertension.
Treated 25 patients with newly diagnosed or poorly regulated essential hypertension using perindopril, adding isradipine and hydralazine if diastolic blood pressure remained above 90 mmHg.
Obtained gluteal subcutaneous biopsies at baseline and after 9 months of successful treatment to isolate small resistance arteries and measure media:lumen ratio via myography.
Assessed changes in left ventricular mass using echocardiography.
Mean (SD) media:lumen ratio of isolated resistance arteries decreased significantly from 9.8 (2.6)% to 7.8 (1.9)% (p < 0.05).
Mean (SD) left ventricular mass decreased from 299 (75) g to 199 (53) g (p < 0.001).
Reductions in left ventricular mass index significantly correlated with decreases in media:lumen ratio (r = 0.62, p < 0.01).

Structured PICO

Does a perindopril-based antihypertensive regimen improve media:lumen ratio and left ventricular mass in patients with essential hypertension?

Population

25 patients with newly diagnosed or poorly regulated essential hypertension

Intervention

Perindopril-based antihypertensive therapy (with addition of isradipine and/or hydralazine if DBP > 90 mmHg) for 9 months

Outcome

Media thickness to lumen diameter (media:lumen) ratio of peripheral resistance vessels and left ventricular mass at 9 monthssurrogate

A perindopril-based antihypertensive regimen significantly reduces peripheral resistance vessel media:lumen ratio and left ventricular mass in patients with essential hypertension over 9 months.

Cite This Study

Sihm et al. (1995) studied this question.

synapsesocial.com/papers/6a7717a5656dd99464ec32b4 https://doi.org/10.3109/08037059509077602

Topics

Hypertension management

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Implication

May support vascular and cardiac remodeling with perindopril in essential hypertension; hypothesis-generating and should not yet change practice.

Normalization of Structural Cardiovascular Changes During Antihypertensive Treatment with a Regimen Based on the ACE-inhibitor Perindopril

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Normalization of Structural Cardiovascular Changes During Antihypertensive Treatment with a Regimen Based on the ACE-inhibitor Perindopril

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider