January 1, 2004The American Journal of Geriatric Cardiology

Diastolic Dysfunction in the Elderly—The Interstitial Issue

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Why the study?

Does inhibition of the renin-angiotensin-aldosterone system improve diastolic function and reduce interstitial collagen in elderly patients with heart failure with preserved ejection fraction?

Population

Elderly patients (≥65 years) with congestive heart failure and preserved left ventricular systolic function

Design

Review

Authors

BBBrad S. BurlewNorthwestern University

Discussion

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Implication

May support RAAS inhibition for diastolic improvement in elderly HFpEF; hypothesis-generating and requires RCT confirmation.

Structured PICO

Does inhibition of the renin-angiotensin-aldosterone system improve diastolic function and reduce interstitial collagen in elderly patients with heart failure with preserved ejection fraction?

Population

Elderly patients (≥65 years) with congestive heart failure and preserved left ventricular systolic function

Intervention

Inhibition of the renin-angiotensin-aldosterone system (ACE inhibitors and aldosterone inhibition)

Outcome

Regression of interstitial collagen volume fraction and improvement in diastolic functionsurrogate

Targeting maladaptive interstitial remodeling via RAAS inhibition may improve diastolic function in elderly patients with heart failure and preserved ejection fraction.

Cite This Study

Brad S. Burlew (2004) studied this question.

synapsesocial.com/papers/6a7724d2f6b553d308ae49d5 https://doi.org/10.1111/j.1076-7460.2004.00059.x

Topics

Heart failure HFrEF treatment Echocardiography

View Full Paper

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Diastolic Dysfunction in the Elderly—The Interstitial Issue

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Diastolic Dysfunction in the Elderly—The Interstitial Issue

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider