Key result
Inactivated poliovirus vaccine (IPV) yielded significantly higher seropositivity for polio type 3 after two doses compared to oral poliovirus vaccine (98-100% vs 92.1%, P<0.001).
Why the study?
Does inactivated poliovirus vaccine (IPV) alone or followed by OPV improve immunogenicity compared to OPV alone in Guatemalan infants?
RCT
Open-label
Yes
Does inactivated poliovirus vaccine (IPV) alone or followed by OPV improve immunogenicity compared to OPV alone in Guatemalan infants?
p-value: p=<.001
In Guatemalan infants, IPV alone or followed by OPV is safe and highly immunogenic, producing higher geometric mean titers than OPV alone.
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Supports IPV-inclusive schedules for superior type 3 immunogenicity in infants; extends RCT data to Guatemalan cohorts.
Asturias et al. (2007) conducted an RCT in Healthy infants. Inactivated poliovirus vaccine (IPV) vs. Oral poliovirus vaccine (OPV) only was evaluated on Seropositivity rate for polio type 3 two months after 2 doses (p=<.001). Inactivated poliovirus vaccine (IPV) yielded significantly higher seropositivity for polio type 3 after two doses compared to oral poliovirus vaccine (98-100% vs 92.1%, P<0.001).
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