Key result
Symptomatic orthostatic hypotension was associated with significantly higher depressive symptom scores (unstandardised B coefficient 2.24) compared to older adults without orthostatic hypotension.
Why the study?
Is symptomatic orthostatic hypotension associated with depression in older adults?
Population
Adults aged 60 and over from the first wave of The Irish Longitudinal Study on Ageing (TILDA).
Comparison
Symptomatic orthostatic hypotension and… vs Participants with no orthostatic hypotension.
Design
Cross-sectional
Authors
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Supports clinical awareness of mood symptoms in older adults with symptomatic orthostatic hypotension; hypothesis-generating for autonomic-vascular mechanisms in late-life depression.
Cross-Sectional (n=3,144)
Is symptomatic orthostatic hypotension associated with depression in older adults?
Mean Difference: 2.24 (95% CI 0.301–4.79)
Absolute Event Rate: 8.6% vs 5.2%
p-value: p=0.05
Symptomatic orthostatic hypotension is significantly associated with higher depression scores in older adults, suggesting a potential link between vascular/autonomic dysfunction and late-life depression.
O’Regan et al. (2013) conducted a cross-sectional in Depression (n=3,144). Symptomatic orthostatic hypotension vs. No orthostatic hypotension was evaluated on Mean score on the 20-item Centre for Epidemiologic Studies Depression scale (CES-D) (unstandardised B coefficient = 2.24, 95% CI 0.301-4.79, p=0.05). Symptomatic orthostatic hypotension was associated with significantly higher depressive symptom scores (unstandardised B coefficient 2.24) compared to older adults without orthostatic hypotension.
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