Why the study?
Does a high-sodium diet and indapamide affect large artery stiffness and aortic wall composition in spontaneously hypertensive rats?
Population
Spontaneously hypertensive rats (SHR)
Comparison
High-sodium (8%) diet and/or indapamide (IND) vs Normal diet
Design
Preclinical
Follow-up
8 weeks
Authors
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High-sodium intake may impair arterial compliance via hyaluronan loss in hypertensive models; leaves open human translation and clinical relevance.
Does a high-sodium diet and indapamide affect large artery stiffness and aortic wall composition in spontaneously hypertensive rats?
A high-sodium diet adversely affects large artery mechanical properties and aortic hyaluronan content in hypertensive rats through pressure-independent mechanisms.
Et-Taouil et al. (2001) studied this question.
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