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December 1, 1986Biochemical JournalOpen Access

Degradation of atrial natriuretic factor in the rat

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Population

Rats (in vivo) and rat whole blood, plasma, and isolated mesenteric artery preparations (in vitro)

Design

Preclinical

Authors

KMKishore K. MurthyCentral Soil Salinity Research InstituteGTGaétan ThibaultHeart Failure / CardiomyopathyRGR. GarcíaUniversidad Complutense de Madrid

Discussion

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Implication

Rapid ANF clearance by vascular enzymes in animals; leaves open relevance to human natriuretic peptide therapeutics.

Structured PICO

P
Population
Rats (in vivo) and rat whole blood, plasma, and isolated mesenteric artery preparations (in vitro)
I
Intervention
Administration or incubation of ANF-(Ser-99-Tyr-126) or 125I-ANF
O
Outcome
Elimination and degradation of ANFsurrogate

The rapid in vivo degradation of ANF appears to be mediated by vascular cells or membrane-bound enzymes rather than circulating plasma proteases.

Cite This Study

Murthy et al. (1986) studied this question.

synapsesocial.com/papers/6a7757caa0847c3df1ec70c5https://doi.org/10.1042/bj2400461
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of a purified atrial natriuretic factor on rat and rabbit vascular strips and vascular beds1984 · 184 citations
  2. 2Natriuretic activity of extracts obtained from hearts of different species and from various rat tissues1983 · 95 citations
  3. 3Primary structure of a high Mr form of rat atrial natriuretic factor1984 · 118 citations
  4. 4Natriuretic activity of human and monkey atria.1983 · 48 citations
  5. 5Cardiovascular effects of atrial extracts in anesthetized rats1984 · 131 citations