February 1, 1995Circulation Research

Activation of Mitogen-Activated Protein Kinase in Porcine Carotid Arteries

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Population

Porcine carotid arteries

Comparison

Mechanical load and pharmacological stimulation vs Unloaded muscle strips (basal state)

Design

Preclinical

Follow-up

up to 60 minutes

Authors

LALeonard P. AdamBristol-Myers Squibb (United States)MFMichael FranklinGarvan Institute of Medical Research GRG.J. RaffIndiana University – Purdue University Indianapolis

Discussion

Member takes

Implication

Suggests MAPK may modulate load-dependent vascular contractility in animals; leaves open human relevance and therapeutic targeting.

Structured PICO

Population

Porcine carotid arteries

Intervention

Mechanical load and pharmacological stimulation (KCl 110 mmol/L or phorbol 12,13-dibutyrate [PDBu] 1 μmol/L)

Comparator

Unloaded muscle strips (basal state)

Outcome

MAPK activitysurrogate

MAPK activity in vascular smooth muscle is upregulated by mechanical load and pharmacological stimulation, suggesting a role in modulating contractility.

Cite This Study

Adam et al. (1995) studied this question.

synapsesocial.com/papers/6a775edcd3a6aa87c6bdb7fe https://doi.org/10.1161/01.res.76.2.183

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