Angiotensin II via Activation of Type 1 Receptor Upregulates Expression of Endoglin in Human Coronary Artery Endothelial Cells
Why the study?
Does Angiotensin II upregulate endoglin expression in human coronary artery endothelial cells?
Population
Human coronary artery endothelial cells
Comparison
Angiotensin II (up to 10 mol/L for up to 24 hours) vs Control and co-incubation with blockers
Design
Preclinical
Follow-up
24 hours (incubation time)
Authors
Discussion
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Member takes
Implication
May inform endothelial mechanisms in vascular injury; leaves open any role for endoglin targeting in human hypertension.
Structured PICO
Does Angiotensin II upregulate endoglin expression in human coronary artery endothelial cells?
P
Population
Human coronary artery endothelial cells
I
Intervention
Angiotensin II (up to 10(-6) mol/L for up to 24 hours)
C
Comparator
Control (no Angiotensin II) and co-incubation with blockers (losartan, PD 123,319, PD 098,059)
O
Outcome
Expression of endoglinsurrogate
Angiotensin II upregulates endoglin expression in human coronary artery endothelial cells via the AT1 receptor and MAPK pathway, providing insight into its role in vascular remodeling after injury.
Cite This Study
Li et al. (2001) studied this question.