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January 19, 2015Muscle & Nerve

A 12-week supervised, home-based progressive resistance training exercise program was feasible and safe in children with SMA, with 90% of visits occurring per protocol and no adverse events.

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Why the study?

Is a home-based, supervised progressive resistance strength training exercise program feasible and safe in children with SMA types II and III?

Population

9 children with spinal muscular atrophy (SMA) types II and III, aged 10.4 ± 3.8 years.

Design

Case_series

Follow-up

12 weeks

Key result

A 12-week supervised, home-based progressive resistance training exercise program was feasible and safe in children with SMA, with 90% of visits occurring per protocol and no adverse events.

Authors

ALAga LeweltKKKristin J. KrosschellGSGregory J. Stoddard

Discussion

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Member takes

Overview

Should not yet change practice in SMA; leaves open larger randomized trials of home-based resistance training.

Structured PICO

Is a home-based, supervised progressive resistance strength training exercise program feasible and safe in children with SMA types II and III?

P
Population
9 children with spinal muscular atrophy types II and III, mean age 10.4 years, who completed a 12-week home-based resistance training exercise program.
I
Intervention
Home-based, supervised progressive resistance strength training exercise program (up to 14 bilateral proximal muscles exercised 3 times weekly for 12 weeks).
O
Outcome
Feasibility, safety, and effects on strength and motor functionsafety

A 12-week supervised, home-based progressive resistance training program is feasible, safe, and well tolerated in children with SMA types II and III.

Cite This Study

Lewelt et al. (2015) studied Spinal muscular atrophy types II and III (n=9). Home-based, supervised progressive resistance strength training exercise program was evaluated on Feasibility, safety, and effects on strength and motor function. A 12-week supervised, home-based progressive resistance training exercise program was feasible and safe in children with SMA, with 90% of visits occurring per protocol and no adverse events.

synapsesocial.com/papers/6a778ca1137c7dcc81bde5dahttps://doi.org/10.1002/mus.24568
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Physical exercise training for type 3 spinal muscular atrophy2019 · 65 citations
  2. 2The Effect of Aerobic Exercise Training on Patients with Type III Spinal Muscular Atrophy2025 · 1 citations
  3. 3Efficacy of Rehabilitation Interventions in Children with Spinal Muscular Atrophy to Improve Their Motor Function: Systematic Review2025
  4. 4Effects of physical therapy on motor ability in patients with spinal muscular atrophy III: a study protocol for a randomised controlled trial2025 · 1 citations
  5. 5Effects of physical therapy on motor ability in patients with spinal muscular atrophy III: a study protocol for a randomised controlled trial2025