Key result
A higher fat-to-lean mass ratio was associated with a significantly increased risk of all-cause death (HR 3.61; 95% CI 1.07-12.13; p=0.038) and cardiac events in patients undergoing hemodialysis.
Why the study?
Does a higher fat-to-lean mass ratio predict cardiac events and all-cause mortality in patients undergoing hemodialysis?
Cohort (n=131)
Does a higher fat-to-lean mass ratio predict cardiac events and all-cause mortality in patients undergoing hemodialysis?
Hazard Ratio: 3.61 (95% CI 1.07–12.13)
p-value: p=0.038
The fat-to-lean mass ratio is an independent predictor of cardiac events and all-cause mortality in patients undergoing hemodialysis, serving as a useful surrogate marker of nutritional and inflammatory status.
May refine nutritional risk assessment beyond BMI in HD; leaves open whether modifying F/L improves outcomes.
BACKGROUND: Although higher body mass index (BMI) is associated with better survival in patients undergoing dialysis, BMI is not an adequate obesity indicator. We hypothesized that the fat-to-lean (F/L) mass ratio could be a suitable marker of nutritional status and evaluated its prognostic impact on long-term outcomes in patients undergoing hemodialysis (HD). METHODS: In total, 131 patients undergoing HD were recruited and monitored prospectively for up to 5 years. Body composition was analyzed, and other nutritional and inflammatory parameters were measured. RESULTS: The mean age of the cohort was 60.7 ± 13.6 years, and 65 patients were diabetic. Age, sex, diabetes, comorbidity, and inflammation were associated significantly with the F/L mass ratio. During the follow-up period, 21 patients experienced cardiac events and 22 patients died. Patients with higher F/L mass ratios had significantly higher risks of all-cause death (hazard ratio [HR] 3.61, 95% CI 1.07-12.13; p = 0.038) and cardiac events (HR 3.54, 95% CI 1.05-11.94; p = 0.041) than those with lower F/L mass ratios. CONCLUSIONS: The F/L mass ratio was a useful surrogate marker of nutritional and inflammatory status, and an independent predictor of cardiac events and all-cause mortality, in patients undergoing HD.
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Lee et al. (2018) conducted a cohort in Hemodialysis (n=131). Higher fat-to-lean mass ratio vs. Lower fat-to-lean mass ratio was evaluated on All-cause death (HR 3.61, 95% CI 1.07-12.13, p=0.038). A higher fat-to-lean mass ratio was associated with a significantly increased risk of all-cause death (HR 3.61; 95% CI 1.07-12.13; p=0.038) and cardiac events in patients undergoing hemodialysis.
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