Why the study?
Body composition affects heart failure prognosis, but the prognostic value of lean body mass and fat mass in patients with HFpEF remains unclear.
Does lean body mass index and fat mass index affect the risk of adverse events in patients with HFpEF?
Does lean body mass index and fat mass index affect the risk of adverse events in patients with HFpEF?
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In HFpEF patients, higher fat mass index is associated with worse outcomes, whereas higher lean body mass index is associated with reduced all-cause mortality.
BACKGROUND: Previous studies have shown that body composition influences the prognosis of heart failure patients; however, the prognostic value of lean body mass and fat mass in patients with heart failure with preserved ejection fraction (HFpEF) remains unclear. This study aimed to investigate the association of lean body mass index and fat mass index with the prognostic outcomes in patients with HFpEF. METHODS: We performed a post hoc analysis of data from the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist (TOPCAT) trial to assess the relationship between Lean BMI and FMI with the adverse events. The primary endpoint was defined as a composite of cardiovascular death, aborted cardiac arrest, or heart failure hospitalization. RESULTS: A total of 3,320 patients were included, with a median follow-up of 3.3 years. Among them, 624 occurred a primary endpoint event, and 503 died. Lean BMI was not associated with the primary endpoint (HR 0.98, 95% CI 0.82-1.16) but was found to reduce the risk of all-cause mortality (HR 0.74, 95% CI 0.61-0.91). In contrast, FMI was associated with an increased risk of both the primary endpoint (HR 1.29, 95% CI 1.09-1.55) and all-cause mortality (HR 1.46, 95% CI 1.19-1.79). CONCLUSION: In patients with HFpEF, a higher FMI was strongly associated with increased risks of both the primary endpoint and all-cause mortality, while an elevated LBMI was associated with a reduced risk of mortality.
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Su et al. (2025) studied this question.
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