Key result
Lower lean body mass index predicts ~55% higher 1-year MACE risk after PCI.
Why the study?
Little is known about the relationship between body composition indicators including BMI, FMI, and LBMI and adverse outcomes after PCI in Asian populations.
Does lower lean body mass index predict major adverse cardiac events in Asian patients with coronary heart disease undergoing PCI?
Population
1857 Asian patients with coronary heart disease undergoing PCI
Comparison
Lower LBMI tertile vs higher LBMI tertiles
Design
Prospective observational multicenter cohort registry
Follow-up
1 year
Authors
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Lower LBMI was associated with higher MACE after PCI in Asians; extends BMI paradox data but leaves open prospective validation before clinical use.
Cohort (n=1,857)
Yes
Does lower lean body mass index predict major adverse cardiac events in Asian patients with coronary heart disease undergoing PCI?
Hazard Ratio: 1.55 (95% CI 1.05–2.3)
p-value: p=<0.001
Lower lean body mass index is a better predictor of 1-year major adverse cardiac events than BMI or fat mass index in Asian patients undergoing PCI.
Hioki et al. (2015) conducted a cohort in Coronary heart disease (n=1,857). Lower lean body mass index (LBMI) vs. Higher LBMI was evaluated on Major adverse cardiac events (MACE), including all cause death, non-fatal myocardial infarction and ischaemic stroke at 1 year (HR 1.55, 95% CI 1.05 to 2.30, p=<0.001). Lower lean body mass index was predictive of a higher 1-year incidence of major adverse cardiac events in patients with coronary heart disease undergoing PCI (HR 1.55; 95% CI 1.05-2.30).
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