Body Mass Index and Adverse Cardiovascular Outcomes in Heart Failure Patients With Preserved Ejection Fraction
Why the study?
Does body mass index affect the risk of death or cardiovascular hospitalization in patients with heart failure with preserved ejection fraction?
Population
4,109 patients with heart failure with preserved ejection fraction, mean age 72 years, from the I-PRESERVE…
Comparison
Body mass index categories: <23.5, 23.5 to 26.4… vs BMI 26.5 to 30.9 kg/m2 (reference group)
Design
Cohort
Follow-up
mean 49.5 months
Authors
Discussion
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Member takes
Implication
BMI extremes may elevate risk in HFpEF; leaves open whether weight optimization improves outcomes.
Structured PICO
Does body mass index affect the risk of death or cardiovascular hospitalization in patients with heart failure with preserved ejection fraction?
P
Population
4,109 patients with heart failure with preserved ejection fraction (HFPEF), mean age 72 years, from the I-PRESERVE trial.
I
Intervention
Body mass index (BMI) categories: <23.5, 23.5 to 26.4, 31 to 34.9, and ≥35 kg/m2
C
Comparator
BMI 26.5 to 30.9 kg/m2 (reference group)
O
Outcome
Composite outcome of death or cardiovascular hospitalizationcomposite
In patients with HFpEF, there is a U-shaped relationship between BMI and adverse cardiovascular outcomes, with the highest risk observed in the lowest (<23.5 kg/m2) and highest (≥35 kg/m2) BMI categories.
Cite This Study
Haass et al. (2011) studied this question.