Why the study?
Does a single amino acid substitution in the adenovirus fiber protein alter binding to human conjunctival cells?
Population
Human conjunctival cells and subgroup D Adenoviruses (Ad37, Ad19p)
Comparison
Amino acid substitution in the Ad19p fiber… vs Wild-type Ad19p and Ad37
Design
Preclinical
Authors
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Identifies fiber residue as key for conjunctival tropism in models; leaves open clinical relevance for human ocular adenovirus disease.
Does a single amino acid substitution in the adenovirus fiber protein alter binding to human conjunctival cells?
A specific amino acid residue in the adenovirus fiber protein is a critical determinant of host cell tropism for human conjunctival cells.
Huang et al. (1999) studied this question.
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