Why the study?
Is endothelial dysfunction associated with high residual platelet reactivity in patients with stable coronary artery disease on dual antiplatelet therapy?
Population
103 patients with stable coronary artery disease who lacked CYP2C19*2 or *3 loss-of-function alleles
Design
Cross-sectional
Authors
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Endothelial dysfunction may identify high residual platelet reactivity on DAPT; hypothesis-generating and should not yet change practice.
Is endothelial dysfunction associated with high residual platelet reactivity in patients with stable coronary artery disease on dual antiplatelet therapy?
Endothelial dysfunction is independently correlated with high residual platelet reactivity in stable CAD patients on dual antiplatelet therapy, independent of CYP2C19 loss-of-function alleles.
Fujisue et al. (2013) studied this question.
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