March 1, 1998Hypertension

Amlodipine Monotherapy, Angiotensin-Converting Enzyme Inhibition, and Combination Therapy With Pacing-Induced Heart Failure

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Why the study?

Does amlodipine, fosinopril, or their combination improve hemodynamics and neurohormonal activity in a pig model of pacing-induced heart failure?

Population

32 pigs instrumented for hemodynamic and neurohormonal measurements, subjected to rapid atrial pacing for 3…

Comparison

Amlodipine monotherapy, fosinopril monotherapy… vs Rapid pacing only (no drug therapy).

Design

Preclinical

Follow-up

3 weeks

Authors

SKScott B. KribbsAtrium Health Wake Forest Baptist WMWilliam M. MerrittGynecologic Oncology Group MCMark J. ClairMedical University of South Carolina

Discussion

Member takes

Implication

Supports preclinical rationale for amlodipine-ACE inhibitor combination in heart failure; leaves open translation to clinical practice.

Structured PICO

Does amlodipine, fosinopril, or their combination improve hemodynamics and neurohormonal activity in a pig model of pacing-induced heart failure?

Population

32 pigs instrumented for hemodynamic and neurohormonal measurements, subjected to rapid atrial pacing (240 bpm) for 3 weeks to induce heart failure.

Intervention

Amlodipine monotherapy (1.5 mg/kg/day), fosinopril monotherapy (1.0 mg/kg BID), or combination therapy of amlodipine (1.0 mg/kg/day) and fosinopril (1.0 mg/kg BID).

Comparator

Rapid pacing only (no drug therapy).

Outcome

Left ventricular function, hemodynamics (cardiac index, total systemic resistance index), and neurohormonal system activity (plasma catecholamines, renin activity, and endothelin levels).surrogate

In a pig model of pacing-induced heart failure, combining amlodipine with ACE inhibition provided greater improvements in vascular resistance and neurohormonal activity than either monotherapy.

Cite This Study

Kribbs et al. (1998) studied this question.

synapsesocial.com/papers/6a77bdbbde5e3adfbdf7367b https://doi.org/10.1161/01.hyp.31.3.755

Topics

HFrEF treatment Heart failure HFpEF management

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Amlodipine Monotherapy, Angiotensin-Converting Enzyme Inhibition, and Combination Therapy With Pacing-Induced Heart Failure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Amlodipine Monotherapy, Angiotensin-Converting Enzyme Inhibition, and Combination Therapy With Pacing-Induced Heart Failure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider