Population
Adult rat hearts, specifically left ventricular papillary muscles (n=15 animals, 5 per group)
Comparison
Longitudinal splitting of papillary muscles in… vs Whole left ventricular papillary muscles (Whole)
Design
Preclinical
Authors
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Validates BDM-assisted splitting for small cardiac muscle samples in animals; leaves open translation to human myocardium or clinical use.
Splitting papillary muscles in the presence of BDM preserves normal energetic and mechanical properties, validating its use for preparing small muscle samples without inducing myocardial damage.
Kiriazis et al. (1995) studied this question.
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