The calibration of BCT/441 provides a secondary international reference preparation with an assigned ISI of 1.04 to promote prothrombin time standardization in oral anticoagulant control.
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May aid consistent INR reporting in oral anticoagulant care; extends calibrated international reference materials for laboratory standardization.
An international collaborative exercise has been undertaken to calibrate a secondary international reference preparation (IRP) of thromboplastin on behalf of the International Committee for Standardization in Haematology (ICSH). This preparation of British Comparative Thromboplastin (BCT/441) is required because supplies of the WHO primary IRP (BCT/253) are necessarily limited. The calibration was performed at seven centres with only a small degree of interlaboratory variation. As a result of this study an ISI value of 1.04 has been assigned to the preparation. Opportunity was also taken to assess the reliability of a simplified calibration based on lyophilised plasmas. The results of the latter appeared reliable. BCT/441 will be available to officially designated National Control Laboratories for calibration of local thromboplastins to promote prothrombin time standardization in oral anticoagulant control.
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Thomson et al. (1986) studied this question.
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