What question did this study set out to answer?

Calibrate five thromboplastin reference preparations against the primary World Health Organization international reference preparation to standardize prothrombin time measurements.

January 1, 1983Thrombosis and Haemostasis

A Collaborative Calibration Study of Reference Materials for Thromboplastins

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Authors

JHJ. HermansLudwig-Maximilians-Universität München ABA.M.H.P. van den BesselaarLeiden University Medical Center ELE.A. LoeligerNetherlands Organisation for Applied Scientific Research

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Implication

Multicenter calibration study reveals log-linear relationships across human, bovine, and rabbit thromboplastin reference standards, indicating reliable standardization for prothrombin time testing.

Key Points

Calibrate five thromboplastin reference preparations against the primary World Health Organization international reference preparation to standardize prothrombin time measurements.
Conducted a collaborative calibration trial across ten laboratories under the European Community Bureau of Reference framework.
Evaluated five thromboplastin preparations derived from human brain (BCT/099), bovine tissue (OBT/79, 68/434), and rabbit tissue (RBT/79, 70/178) against primary WHO reference material 67/40.
Modeled calibration relations using linear regression between the logarithms of prothrombin times measured in seconds.
Successfully established calibration relationships for three Community Bureau of Reference materials and two secondary WHO international reference preparations.
Demonstrated that prothrombin time responses across human, bovine, and rabbit thromboplastin preparations exhibit a linear relationship on a logarithmic scale relative to the primary standard.

Cite This Study

Hermans et al. (1983) studied this question.

synapsesocial.com/papers/6a7c22df169fe1af7cc2a71c https://doi.org/10.1055/s-0038-1665293

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Implication

Multicenter calibration study reveals log-linear relationships across human, bovine, and rabbit thromboplastin reference standards, indicating reliable standardization for prothrombin time testing.

A Collaborative Calibration Study of Reference Materials for Thromboplastins

Discussion

Member takes

Implication

Key Points

Cite This Study

A Collaborative Calibration Study of Reference Materials for Thromboplastins

Discussion

Member takes

Implication

Key Points

Cite This Study

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