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January 1, 1964Experimental Biology and Medicine

Cell Culture Studies on Antiviral Agents: I. Action of Cytosine Arabinoside and Some Comparisons with 5-Iodo-2-Deoxyuridine.

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Population

Cell cultures infected with DNA viruses, adenoviruses, and RNA viruses

Comparison

Cytosine arabinoside (CA) vs 5-Iodo-2-Deoxyuridine

Design

Preclinical

Authors

DBD. A. ButhalaArgonne National Laboratory

Discussion

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Implication

Does not justify clinical use; hypothesis-generating for selective DNA antiviral agents in preclinical models.

Structured PICO

P
Population
Cell cultures infected with DNA viruses (herpes simplex, B-virus, pseudorabies, vaccinia, swine pox, fowl pox), adenoviruses, and RNA viruses
I
Intervention
Cytosine arabinoside (CA)
C
Comparator
5-Iodo-2-Deoxyuridine
O
Outcome
Antiviral activitysurrogate

Cytosine arabinoside demonstrates selective in vitro antiviral activity against specific DNA viruses.

Cite This Study

D. A. Buthala (1964) studied this question.

synapsesocial.com/papers/6a77cbc998f24dbf64bd9d13https://doi.org/10.3181/00379727-115-28834
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Also Consider

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  1. 1Antiviral Profiling and Cellular Activation of Carbobicyclic Nucleoside Analogues2026 · 1 citations
  2. 23-Deazauridine: Inhibition of Ribonucleic Acid Virus-Induced Cytopathogenic Effects In Vitro1972 · 36 citations
  3. 3Synthesis and Antiviral Activity of 5-Substituted Cytidine Analogues: Identification of a Potent Inhibitor of Viral RNA-Dependent RNA Polymerases2006 · 46 citations
  4. 42′-Fluoro-2′-Deoxycytidine Inhibits Borna Disease Virus Replication and Spread2004 · 17 citations
  5. 5Possible molecular basis for antiviral activity of certain 5-substituted deoxyuridines1983 · 13 citations