Why the study?
Does intramuscular chlorpromazine improve hemodynamics and symptoms in patients with acute left-sided heart failure?
Population
18 patients with acute left-sided heart failure (10 in treated group, 8 in control group)
Comparison
Intramuscular injection of chlorpromazine 5 to… vs No injection of chlorpromazine
Design
Cohort
Follow-up
6 hours
Authors
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May support rapid hemodynamic effects of intramuscular chlorpromazine in acute left-sided HF; hypothesis-generating and requires randomized confirmation before practice change.
Does intramuscular chlorpromazine improve hemodynamics and symptoms in patients with acute left-sided heart failure?
Intramuscular chlorpromazine rapidly reduces left ventricular filling pressure and improves symptoms of pulmonary congestion in patients with acute left-sided heart failure.
Mifune et al. (1979) studied this question.
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