Why the study?
Does chronic constriction of the ascending aorta alter vasomotor responses and dynamic compliance in the distal aorta in guinea pigs?
Population
Guinea pigs
Comparison
Chronic constriction of the ascending aorta vs Sham operation
Design
Preclinical
Follow-up
149+/-6 days
Authors
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May indicate compensatory distal aortic vasodilation in experimental HF; leaves open relevance to human hypotension or syncope.
Does chronic constriction of the ascending aorta alter vasomotor responses and dynamic compliance in the distal aorta in guinea pigs?
In a guinea pig model of heart failure due to aortic stenosis, increased endothelium-mediated vasodilatation in the distal aorta may contribute to hypotension and syncope.
Kingsbury et al. (1999) studied this question.
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