Population
Anaesthetized rats and neonatal (postnatal days 6-10) tyrosine hydroxylase (TH)-GFP transgenic mice
Design
Preclinical
Authors
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A5 neurons may mediate renal sympathetic responses to hypoxia in rodents; leaves open their relevance to human cardiovascular pathophysiology.
Adult A5 noradrenergic neurons are vigorously activated by carotid body stimulation, likely contributing to increased visceral sympathetic nerve activity during acute hypoxia, but have limited sensitivity to local brain pH or PCO2 changes.
Kanbar et al. (2010) studied this question.
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