Key result
Medullary C1 neurons activated by hypoxia project directly to pontine A5 neurons, and glutamatergic receptor blockade in the A5 node suppresses sympathetic and respiratory responses to C1 activation.
Population
Adult male rats
Comparison
Various experimental techniques including… vs Contralateral neuronal count or baseline responses
Design
Editorial
Authors
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The C1-A5 neural pathway forms an intrinsic component of the chemoreflex circuitry mediating sympathoexcitation and the pressor response to stress.
The C1-A5 neural pathway forms an intrinsic component of the chemoreflex circuitry mediating sympathoexcitation and the pressor response to stress.
Ken D. O’Halloran (2021) conducted an editorial in Cardiorespiratory control. Glutamatergic receptor blockade in the A5 region / selective optogenetic activation of C1 neurons vs. Contralateral neuronal count / baseline was evaluated on Blood pressure, splanchnic sympathetic nerve activity, and phrenic nerve motor activity. Medullary C1 neurons activated by hypoxia project directly to pontine A5 neurons, and glutamatergic receptor blockade in the A5 node suppresses sympathetic and respiratory responses to C1 activation.
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