Key result
Bilateral A5 noradrenergic inhibition reduces hypercapnia-induced increases in MAP, sSNA, and PNA in rats.
Population
Urethane anaesthetized sino-aortic denervated and vagotomized male Wistar rats (n = 8/group)
Comparison
Bilateral injection of muscimol or immunotoxin… vs Control response to hypercapnia without A5…
Design
Preclinical
Authors
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A5 contribution to central chemoreflex remains unproven in rats; leaves open any translational role in human autonomic control.
A5 noradrenergic neurons contribute to the increase in mean arterial pressure, sympathetic nerve activity, and phrenic nerve activation during central chemoreflex stimulation in rats.
Moreira et al. (2011) studied Central chemoreflex stimulation. Bilateral inhibition of A5 region (muscimol or anti-DβH-SAP) vs. Hypercapnia alone (baseline response) was evaluated on Changes in mean arterial pressure (MAP), sympathetic nerve activity (sSNA), and phrenic nerve activity (PNA). Bilateral inhibition of the A5 noradrenergic region reduced the hypercapnia-induced increases in mean arterial pressure, sympathetic nerve activity, and phrenic nerve activity in rats.
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