Key result
Selective destruction of C1 neurons with anti-DβH-SAP reduced the increase in minute ventilation elicited by hypoxia (244 vs. saline 402 ml/kg/min) but did not alter hypercapnia responses.
Population
Adult unanesthetized male Wistar rats (270-300g, N = 4-7/group)
Comparison
Bilateral injection of the immunotoxin… vs Saline injection
Design
Preclinical
Authors
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C1 neuron ablation blunts hypoxic ventilatory response in rats; hypothesis-generating for their role in human hypoxia, should not change practice.
Absolute Event Rate: 244% vs 402%
Selective destruction of C1 neurons in the ventrolateral medulla blunts the hypoxic ventilatory response in unanesthetized rats, suggesting their involvement in respiratory control during hypoxia.
Malheiros‐Lima et al. (2015) studied hypoxia or hypercapnia. anti-dopamine β-hydroxylase-saporin (anti-DβH SAP) vs. saline was evaluated on minute ventilation (MV) elicited by hypoxia (8% O2). Selective destruction of C1 neurons with anti-DβH-SAP reduced the increase in minute ventilation elicited by hypoxia (244 vs. saline 402 ml/kg/min) but did not alter hypercapnia responses.
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